Genome Editing And Engineering

12 weeks

@VTU COE

2.0
(2) 43 Students
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What you will learn

  • structure of genome

  • genome editing tools

This course is designed for UG & PG students, research scholars and young scientists to introduce them to basics and applications of genome editing and engineering. The course starts with understanding of basic organization and structure of genome. It gives a brief overview on different DNA strand breaks and their repair mechanism. It introduces learners to theoretical basics of genetic engineering and discusses it’s limitations in tackling genetic problems of animals and plants. The key concepts of Genome editing are discussed thoroughly with emphasis on the major genome editing tools ZFN, TALEN and CRISP/Cas9. It discusses the biochemical basis of development of the genome editing tools, their design and their applications in various genetic conditions. It also discusses the scope and prospect of using these technologies in solving major genetic disease of human. The learners will also be acquainted with the ethical concerns associated with applications of genome editing and engineering in germline.

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Lec 4: Breakage of Genomic DNA
Preview 45:00
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Lec 5: Repair of Genomic DNA
Preview 56:42

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Lec 6: Homologous and non homologous recombination
Preview 58:12
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Lec 7: Site specific recombination
Preview 41:03

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Lec 8: Targeted genetic modification - I
Preview 50:40
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Lec 9: Targeted genetic modification - II
Preview 59:23

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Lec 10: Basics of Zinc Finger Nucleases
Preview 51:27
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Lec 11: Design of Zinc Finger Nucleases for genome editing
Preview 62:27
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Lec 12: Applications of Zinc Finger Nucleases - PART A
Preview 32:32
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Lec 13: Applications of Zinc Finger Nucleases - PART B
Preview 31:33

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Lec 14: Basics of TALEN - PART A
Preview 25:22
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Lec 15: Basics of TALEN - PART B
Preview 35:33
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Lec 16: Design of TALEN for genome editing - PART A
Preview 35:01
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Lec 17: Design of TALEN for genome editing - PART B
Preview 23:29
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Lec 18: Application of TALEN - Part A
Preview 34:46
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Lec 19: Application of TALEN - Part B
Preview 39:28

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Lec 20: CRISPR system in bacteria - Part A
Preview 47:26
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Lec 21: CRISPR system in bacteria - Part B
Preview 30:39
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Lec 22: CRISPR/Cas9 in Genome Editing - Part A
Preview 35:53
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Lec 23: CRISPR/Cas9 in Genome Editing - Part B
Preview 36:34
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Lec 24: Applications of CRISPR/Cas9 Part A
Preview 30:58
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Lec 25: Applications of CRISPR/Cas9 Part B
Preview 29:55
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Lec 26: Computational Resources for CRISPR / Cas - Part A
Preview 35:03
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Lec 27: Computational Resources for CRISPR / Cas - Part B
Preview 27:11

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Lec 28: Human cell engineering in diseases : Thalassemia - Part A
Preview 33:54
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Lec 29: Human cell engineering in diseases : Thalassemia - Part B
Preview 36:42
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Lec 30: Human cell engineering in diseases : Severe combined immunodeficiency (SCID) - Part A
Preview 44:34
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Lec 31: Human cell engineering in diseases : Severe combined immunodeficiency (SCID) - Part B
Preview 32:28
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Lec 32: Human cell engineering in diseases : Hemophilia - Part A
Preview 36:54
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Lec 33: Human cell engineering in diseases : Hemophilia - Part B
Preview 37:51

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Lec 34: Animal models - Part A
Preview 32:59
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Lec 35: Animal models - Part B
Preview 41:37
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Lec 36: iPSc models - Part A
Preview 52:37
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Lec 37: iPSc models - Part B
Preview 34:57
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Lec 38: Cancer disease models - Part A
Preview 31:31
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Lec 39: Cancer disease models - Part B
Preview 26:31

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Lec 40: Engineered immune cells for Cancer therapy (I) - Part A
Preview 29:56
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Lec 41: Engineered immune cells for Cancer therapy (I) - Part B
Preview 33:24
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Lec 42: Engineered immune cells for Cancer therapy (II) - Part A
Preview 22:37
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Lec 43: Engineered immune cells for Cancer therapy (II) - Part B
Preview 29:03

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Lec 44: History and Basics - Part A
Preview 31:39
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Lec 45: History and Basics - Part B
Preview 28:21
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Lec 46: Genome editing and personalized therapy
Preview 32:51

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Lec 47: Bioethics and Biosafety - Part A
Preview 28:14
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Lec 48: Bioethics and Biosafety - Part B
Preview 23:17
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Lec 49: Regulatory issues in Genome Editing
Preview 39:17
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2.0

2 Reviews

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user
Madhushree K V

9 months ago

When will the exam dates and assignment be given..??...we have applied for honours it will become difficult if information is not provided at the earliest..... Please look into this problem asap

user
Sushma Ranjini M S

9 months ago

kindly mention the type of exam (whether its core or objective ) for all the courses

Meet Your Instructor
@VTU COE
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Instructor
3.2 Rating
2542 Students
759 Courses
About Instructor

VTU is one of the largest Technological Universities in India with 24 years of Tradition of excellence in Engineering & Technical Education, Research and Innovations. It came into existence in the year 1998 to cater the needs of Indian industries for trained technical manpower with practical experience and sound theoretical knowledge.

video

Free

  • Course Duration
    31 h 27 m 16 s
  • Course Level
    Intermediate
  • Student Enrolled
    43
  • Language
    English
This Course Includes
  • 31 h 27 m 16 s Video Lectures
  • 2 Quizzes
  • 0 Assignments
  • 0 Downloadable Resources
  • Full Lifetime Access
  • Certificate of Completion